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[171] synthesized the phosphate monoesters of NBDHEX and MC3181 (Figure 7E,F), which showed high water solubility and potent GSTP1 inhibitory activity and therefore exhibited promising anti-proliferation effects against human melanoma and osteosarcoma cells, which is implicated as a potential clinical treatment for melanoma

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In mouse models of melanoma metastasis, G6PD deficiency decreases circulating melanoma cells and the metastatic burden 149

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