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These effects are achieved through four coordinated mechanisms: (i) direct scavenging of free radicals such as •OH and O 2 • - , (ii) inhibition of lipid peroxidation chain reactions through suppression of 4-HNE and MDA formation, (iii) antagonism of pathological Ca 2+ overload, and (iv) enhancement of mitochondrial energy synthesis through improved substrate delivery and microcirculatory perfusion ( 5.3 Active components of Saponin-containing plants Terpenoids are another important class of active compounds in plants
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