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a solid or semi-solid substrate e.g., a solid substrate such as an ELISA plate the disclosure also provides an isolated or recombinant TL1a-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain binds specifically to TL1a and inhibits the interaction of biotinylated TL1a and DR3/Fc with an EC 50 of about 2.5 nM or less, such as 1 nM or less or from about 2.5 nM, or about 1.0 nM, or about 0.5 nM, or about 0.1 nM to about 10 fM in a competition ELISA, the DR3/Fc is immobilized on a solid or semi-solid substrate (e.g., a solid substrate such as an ELISA plate) at a concentration of about 2 ⁇ g/mL, and wherein the biotinylated TL1a is contacted for about 30 minutes at a concentration of about 1 ⁇ g/mL with the TL1-a binding protein at a concentration range of from about 10 ⁇ g/mL to about 0.01 ⁇ g/mL and is then contacted to the immobilized DR3/Fc, a solid or semi-solid substrate e.g., a solid substrate such as an ELISA plate the TL1a-binding protein does not detectably reduce interaction of biotinylated TL1a and DcR3/Fc in a competition ELISA compared to the level of the binding of biotinylated TL1a to DcR3/Fc in the absence of the TL1a-binding protein, and wherein the DcR3/Fc is immobilized on a solid or semi-solid substrate (e.g., a solid substrate such as an ELISA plate) at a concentration of about 2 ⁇ g/mL, wherein the biotinylated TL1a is contacted for about 30 minutes at a concentration of about 1 ⁇ g/mL with the TL1a-binding protein at a concentration of from about 10 ⁇ g/mL to 0.1 ⁇ g/mL and is then contacted to the immobilized DcR3/Fc copper-peptide https://cdn11.bigcommerce.com/s-35tuw7jhw2/images/stencil/1280x1280/products/28358/39738/Magnesium_Taurate_90caps_Jarrow_formulas__99300.1743935567.jpg?c=1 Kōloa Village a live-work-play community - Kauaʻi, Hawaiʻi Diameter:4.2mm