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Indeed, inflammatory mediators (including glutamate) produced by reactive neuroglia can trigger intracellular signaling cascades that can alter mitochondrial metabolism including respiratory chain enzyme activity (this may explain increased lactate in the CSF of ME/CFS patients) (Shungu et al., 2012) swollen legs https://www.rch.org.au/uploadedImages/Main/Content/clinicalguide/guideline_index/Anaemia_Guideline.jpg Human Glutathione Synthetase ELISA Kit (ab283966) | Abcam Size:200 µg - Cat. No. A30220200
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