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Adipose-derived stem cells (ADSCs) cocultured with senescent human umbilical vein endothelial cells (HUVECs), when transfected with miR-499a, displayed a broad-spectrum downregulation of senescence associated genes

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CKD and CVD are the common complications of T2DM ( Finerenone is a structurally novel non-steroidal mineralocorticoid receptor antagonist (MRAs), which exhibits outstanding effect on cardio-renal protection ( A number of large-scaled clinical trials have proved that finerenone can significantly reduce both cardiorenal endpoints and the adverse reactions such as electrolyte disorders and sex hormone-like effects ( 2 The mechanism of MR activation on kidney and cardiovascular system 2.1 The physiological action of MR and MRAs The physiological ligands of MR are mainly aldosterone and cortisol