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In literature, placebo-controlled clinical trials involving 1,209 participants, treatment with standardised silymarin formulations, such as Legalon or Silipide, showed no statistically significant improvement in mortality, histological findings, or major biochemical markers of hepatic function compared with the placebo (ClinicalTrials.gov, 2024)
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Should bothersome or serious side effects occur due to this interaction, your doctor will likely have you stop treatment with Wellbutrin, the other antidepressant, or possibly both medications