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Impaired Endothelium-Dependent Hyperpolarization Underlies Endothelial Dysfunction during Early Metabolic Challenge: Increased ROS Generation and Possible Interference with NO Function
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The cytochrome P450 (CYP) isoforms, which have key roles in metabolic pathways of AFB 1 , are stimulated via environmentally relevant levels of AFB 1 (10 and 100 ng/mL) in circulating lymphocytes and monocytes ( 1 -epoxide strongly binds to the cell macromolecules, triggering more oxidative conditions (90)
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