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Meanwhile, ROCK can enhance the transduction of transforming growth factor-β1/suppressor of mothers against decapentaplegic homolog signaling 40 , thereby inducing endothelial-to-mesenchymal transition, increasing fibrosis markers, and structural remodeling of the microvasculature in the CC 41

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If CTH activity is compromised due to genetic variants, it may reduce the body’s ability to produce enough glutathione, making it harder to eliminate toxins and fight free radicals that can damage cells