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Nrf2 is sequestered in the cytoplasm by Kelch-like ECH-associated protein (Keap1) under unstimulated conditions, while Nrf2 is translocated into the nucleus and activates the electrophilic response element/antioxidant response element (EpRE/ARE) upon exposure to oxidative insults [43-45]

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This combination may decrease risks associated with pregnancy complications significantly