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This revelation required a new model for JAK2 activation by cytokine binding whereby in the cytokine free receptor, the JAK2 KD is inhibited by a JAK2 PKD in trans (Figure 2)
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The transformative power of this methodology is best exemplified by the landmark screens that led to the independent discovery of the FSP1-CoQ10-NAD(P)H axis, a powerful antioxidant system that operates in parallel to and is entirely independent of the canonical GPX4 pathway
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