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235 In a controlled trial involving 130 fibromyalgia patients being treated with duloxetine plus pregabalin, the addition of 500 mg of acetyl-L-carnitine plus 600 mg of palmitoylethanolamide (PEA) twice daily for 12 weeks improved Widespread Pain Index, Fibromyalgia Impact Questionnaire, and Fibromyalgia Assessment Status scores more than medical treatment alone

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A significant set of highly regulated proteins (40%) are involved in RNA processing, splicing, protein translation, folding, secretion and degradation (Table 1), suggesting that enhanced ER-mitochondrial tethering affects all aspects of protein homeostasis