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Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society

This helps to prolong their circulation time in the body, enhancing their ability to reach target sites, improving their overall pharmacokinetic profile, and reducing their recognition and clearance by the immune system [31]

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