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There is evidence that the male mouse brain is more susceptible to OS due to lower levels of paraoxonase-2, which is an antioxidant enzyme positively modulated by estradiol 58

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In IPF patients, neutrophils show an increased expression of Nox2 subunits (Kato and Hecker, 2020) and genetic removal of some of these subunits partially protects from the development of fibrosis in lung fibrosis mice models (Manoury et al., 2005