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15 Optimal intake and safety Direct “head-to-head” comparisons of anthocyanin bioavailability and health effects from whole foods versus isolated extracts remain relatively scarce

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Cytosolic GSTs not only catalyze the conjugation of GSH to electrophilic substances (including electrophilic drug metabolites and endogenous electrophiles) and reduction of organic hydroperoxides but also take part in the regulation of cellular signaling pathways, such as the mitogen-activated protein (MAP) kinase pathway, via the inhibition of c-Jun N-terminal kinase 1 (JNK1) and apoptosis signal-regulating kinase 1 (ASK1) [20,192]