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Moreover, we excluded patients and controls who suffered from neurodegenerative and neuroinflammatory disorders, such as chronic fatigue syndrome [54], Parkinson’s or Alzheimer’s disease, multiple sclerosis, stroke, or systemic (auto)immune diseases such as diabetes mellitus, psoriasis, rheumatoid arthritis, inflammatory bowel disease and scleroderma, and liver and renal disease

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Responsiveness Ability of a measurement instrument to detect meaningful change in a particular outcome over time or in response to an effective intervention (sensitivity to change in the condition being measured)