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TCAs are first-line drugs for the prophylaxis of CHS and CVS and have been shown to reduce the duration, severity, and frequency of episodes, as well as the number of emergency department visits and hospitalizations.144 Amitriptyline is usually started at a low dose of 25 mg and gradually increased in increments of 10 mg each week to a target dose of approximately 100 mg at night in adults

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[DOI] [PubMed] [Google Scholar] 230.Maiorino, M., Conrad, M