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Clinically, high LPLA2 expression correlates with poor patient outcomes, underscoring the ATF4/LPLA2/BMP axis as a pivotal driver of alcohol-accelerated HBV-associated HCC (38)
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87 STAT3 also directly binds to the VEGF promoter, as observed in NSCLC, and regulates MMP2 and MMP9 secretion, facilitating ECM degradation and angiogenesis
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