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what is glutathione s transferase S-transferase and MRP1 form an integrated system involved in the
Of interest, GLO1 inhibitors have been shown to reverse the sensitivity of tamoxifen-resistant breast cancer cells, revealing that GLO1 may be a biomarker for predicting the efficacy of endocrine therapies and a target for overcoming treatment resistance (158)
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Overall, this study suggests caution in the use of MTAP status as the sole predictive biomarker for identifying patients to receive MAT2A/PRMT5 inhibitor therapy
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