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Keloid Senescent Fibroblast Elimination & SASP Suppression (Communications Biology, 2025) FOXO4-DRI Induces p53-pS15 Nuclear Exclusion and Apoptosis in Keloid Fibroblast Models A study published in Communications Biology (Nature Publishing Group, 2025) used single-cell RNA sequencing to characterise the senescent cell landscape in keloids — pathological scars with tumour-like aggressiveness

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In the pivotal human study, Teichman 2006 reported that single subcutaneous doses in healthy adults produced dose-dependent increases in mean plasma GH of roughly 2- to 10-fold for six days or more and IGF-I of 1.5- to 3-fold for nine to eleven days, with an estimated half-life of 5.8-8.1 days attributable to the drug-affinity-complex (DAC) technology that binds serum albumin