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4.7.2 TNF and the inhibitors As an anti-inflammatory mediator, TNF-α is considered to play a role in vitiligo, which may promote apoptosis in melanocytes, induce B-cell activation, increase autoantibody production, and inhibit melanogenesis (90)

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In several human cancer types, including liver, skin, colorectal, lung, head and neck, breast, and prostate cancers, GCLC and glutathione levels are increased relative to normal tissue (Gamcsik et al., 2012)