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Only about 40% of patients of the group treated for the same period with ketoconazole cream 2% twice a day were cured or markedly improved (Menendez et al., 2002, 2010)
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6) using PROPKA, C23 was determined to be the most acidic cysteine ( p K a = 5.4) followed by C8 ( p K a = 7.4), both of which are more acidic than the thiol group in GSH ( p K a = 8.7)
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