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When the Mann Whitney U statistic is considered the significantly highest were those which recorded a zero, that included high titres of HMGB1, total cholesterol, NF-kB, and the collagens I and III ( Table 1 ) in the DCM group
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In contrast, physically enhanced methods utilize techniques that bypass the stratum corneum, such as ablation procedures to remove this outer layer or the application of microneedles, which allow for direct drug delivery into the deeper layers of the skin
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