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IGF-1 signaling disruption determines macrophage activation into the pro-inflammatory M1 phenotype and reduces lipid efflux, promoting lipid accumulation in macrophages (119, 147)
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The L-carnitine contributes to restore the energy balance and provide adequate energy reserves to the oocyte during folliculogenesis and maturation and can represent an important strategy to improve the intraovarian environment and increase the probability of pregnancy
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