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Vitamin B12 Deficiency 🔹 Causes megaloblastic (macrocytic) anemia 🔹 Needed for DNA synthesis and neurologic function 🔹 Pernicious anemia = classic cause (lack of intrinsic factor) Causes 🔹 Pernicious anemia 🔹 Vegan
Excessive methyl supplementation — taking too much methylfolate or methyl-B12 for your needs COMT mutations — slow breakdown of neurotransmitters, causing buildup when you add more methyls Histamine issues — methylation can increase histamine in some people
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Anecdotal evidence suggests that taking 1000 mcg of vitamin B12 on a daily basis may help treat the condition
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