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2.1.6 Telomeric DNA damage Telomeric DNA damage is also contributing to the aging process, and telomeric DNA repair efficiency decreases with age (Kruk et al., 1995
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The systemic release of reactive oxygen species (ROS), proinflammatory cytokines, and other mediators amplifies multi-organ injury, leading to increased morbidity and mortality in various clinical contexts, including surgery, trauma, and vascular diseases [5,6]
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