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Exposure to high doses (10–20 mg/kg) promotes lipid peroxidation, increases GSSG levels and decreases GSH, increases IL-1β and TNF-α, decreases SOD, GPx and GR activity in the hippocampus and cortex [38]
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O-GlcNAcylation consists in the enzymatic attachment of N-acetylglucosamine (GlcNAc) to serine and threonine residues of MMPs, in the presence of high levels of glucose
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