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Although a combination therapy regimen is recommended to reduce recurrence and prolong DFS in TNBC, some drugs have side effects, as seen in doxorubicin or platinum agents such as cisplatin, which inhibits DNA synthesis by forming intra- and inter-strand bonds in DNA, but are highly toxic, presenting neurological toxicity (ototoxicity) and nephrotoxicity
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148 Necroptosis and extrinsic apoptosis share initial signaling pathways involving death receptors such as TNFR1 or Fas, but necroptosis occurs in caspase-8-deficient contexts (e.g., inflamed tissues or resistant cancers) via RIPK1/RIPK3/MLKL activation
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