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Annex I: Prohibited list: International Standard
After activation, two important downstream factors of the MAPK signaling pathway, p38 and JNK can enter the nucleus, upregulate the expression of related inflammatory cytokines, induce the expression of matrix metalloproteinases (MMPs), and downregulate the expression of TGF-β, reducing the synthesis of new collagen, thus playing a crucial role in ultraviolet-mediated photoaging (Wei et al., 2024)
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