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Physiologically based pharmacokinetic (PBPK) models employ a mechanistic approach that integrates the physicochemical properties of drugs with established knowledge of human physiology, allowing a quantitative representation of their absorption, distribution, metabolism, and excretion (ADME) ( The objective of this work was to apply PBPK modeling to explore and predict potential drug–drug interactions (DDIs) between ayahuasca constituents and the SSRIs fluoxetine and paroxetine
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This work can help researchers acquire a deeper understanding of the relationship between AGEs and the skin and provides a basis for the development of effective ingredients that inhibit glycation
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