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THE POLYOL PATHWAY The polyol pathway consists of 2 reactions catalyzed by 2 respective enzymes.7, 10, 35 As shown in Figure 1B, the first reaction is reduction of glucose to sorbitol, which is catalyzed by aldose reductase (AR)
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The reduce expression of apical efflux transporter MRP2 is often associated with up-regulation of basolateral efflux transporter MRP3 to limit hepatic toxicity (Keppler and Konig, 2000
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