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This glial metabolic deficiency deprives neurons of lactate-derived pyruvate for mitochondrial oxidative phosphorylation while concurrently impairing lactate-mediated epigenetic regulation of antioxidant genes (e.g., Nrf2), thereby synergistically exacerbating neuronal redox stress and bioenergetic collapse in mood-regulatory circuits [98,99]
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For validation, four LED treatments (30H, 50H, 80H, 100H) were applied to Van cultivar and were compared with the untreated control
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