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By activating the Nrf2/HO-1 pathway, the levels of ROS are reduced, while the levels of solute carrier family 7 member 11 (SLC7A11) are increased, enhancing GPX4 activity
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Notably, metabolites such as AGEs, dysregulated ketone bodies, and BCAAs have been demonstrated to be directly or indirectly associated with structural abnormalities and functional decline in the lung (e.g., impaired surfactant synthesis, diminished respiratory muscle function)
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