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When the glutathione/GSSG redox potential of the bronchoalveolar lavage fluid or the epithelial lining fluid was determined, the alveolar lining fluid was approximately 40 mV more oxidized in subjects with a history of alcoholism
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They are primarily regulated by the transcription factor forkhead box P3 ( FOXP3 ), which is essential for their development, function and their suppressive activity, any mutations in the FOXP3 gene can impair the Tregs activity, leading to autoimmune disorders
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