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These include: Genetics Brain injuries, such as from falls or accidents Medical conditions, such as diabetes or high blood pressure Poor diet Lack of exercise Smoking Toxins Medications or improper use of medications Social isolation and loneliness Reduction in sleep Some of the reasons these factors can reduce brain health are that they increase inflammation in the brain and can also cause a change in the hormone and nutrient levels in the brain (1)

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Tumor cells produce higher numbers of exosomes and exploit them to promote tumor growth by reprogramming the TME that favors tumor proliferation, invasion and metastasis [138,139]