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This upregulation is associated with chromatin remodeling, which is characterized by di- and tri-methylation of histone H3K4 and preferential binding of c-Rel at the p19 promoter, contributing to age-related inflammatory responses
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In particular, we found that the moderate depletion of GSH is operative upon fasting conditions in several organs including skeletal muscle and brain and this event is causative of the augmentation of NO availability
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