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Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression
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The viscosity also increases, but the curve is flatter and peaks around 70 mPa·s before declining slightly, suggesting that the preservative interferes with network formation and reduces the strength of the gel
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