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Reduced T3 levels in hypothyroidism impair Na+/K + ATPase regulation, affecting metabolic equivalents and causing symptoms such as fatigue, weight gain, cold intolerance, anxiety, constipation, hypothermia, decreased appetite and locomotion (Reference Kostoglou-Athanassiou and Ntalles1,Reference Fatourechi2)
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Environmental toxicants induce ROS formation by inhibiting the antioxidant defense system, initiating Fenton reactions (Figure 3a), causing mitochondrial dysfunction, and generating harmful chemical metabolites
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