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These include activation of five major pathways: increased flux of glucose and other sugars via the polyol pathway, increased formation of AGEs, increased expression of RAGE and its activating ligands, activation of protein kinase C (PKC) isoforms, and overactivity of the hexosamine pathway
كريم يوحد لون الرقبة والصدر
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634 AAK1 inhibitor LX-9211: Junctional protein 2-associated kinase 1 (AAK1) is widely expressed in the brain and spinal cord and is a viable target for the treatment of neuropathic pain, and BMS-986176/LX-9211 is a novel class of bis(iso)aryl ethers that are highly selective, CNS-permeable, and potent AAK1 inhibitors
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