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For example, some studies used doses in the range of roughly 25 to 50 micrograms per kilogram of body weight, delivered in controlled clinical settings
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After the boost, four out of six rabbits immunized with E2 displayed HVR1 binding titers, but the difference with E2E1-NP immunized rabbits was still large (38-fold) and significant ( p = 0.0006), while HVR1 binding was now detected in all E2E1-I53-50A trimer immunized rabbits (Fig
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