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(1986) found that DSIP at 10 −9 –10 −7 M reduced CRF-stimulated ACTH release in isolated rat anterior-pituitary tissue
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Kannt and colleagues then found the same pattern in people: patients with type 2 diabetes carried roughly twofold higher NNMT mRNA in both omental and subcutaneous white adipose tissue than controls, and plasma 1-MNA tracked both tissue NNMT expression and the degree of insulin resistance across 199 surgical patients
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