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Frontiers | Bee pollen as a food and feed supplement and a therapeutic remedy: recent trends in nanotechnology
Patients with FM exhibit elevated concentrations of glutamate, a major cortical excitatory neurotransmitter, in the right posterior insula [77] and substance P in the cerebrospinal fluid [22], potentially indicating enhanced pain signaling
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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
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