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102 Dose-dependent studies also show that itaconate inhibits the respiratory activities of complexes II and II + III, reduces ADP- and DNP-stimulated respiration, suppresses complex IV, and promotes calcium-dependent opening of the mitochondrial permeability transition pore with cytochrome c release, culminating in mitochondrial dysfunction
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Strbe et al., 2021), intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and coworkers (Chui et al., 1970) on a scale of 0–5 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 0–15, as described by Lane and coworkers (Lane et al., 1997)
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