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Moreover, increased MMP-2 activity activates the latent form of transforming growth factor (TGF)-β in hypertension by proteolyzing its anchoring proteins such as the latent associated peptide (LAP) and the latent TGF-β binding protein (Ruiz-Ortega et al., 2007) Cadherins are also potential targets of MMPs in the VSMC as the use of MMP inhibitors prevented their proteolysis and reduced VSMC migration and proliferation in vitro (Uglow et al., 2003)
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