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Contact your GP if you notice: Persistent abdominal pain or discomfort , particularly in the upper right abdomen Jaundice —yellowing of the skin or whites of the eyes Unexplained fatigue that significantly impacts daily activities Unintentional weight loss or loss of appetite Dark urine or pale, clay-coloured stools Swelling in the legs, ankles, or abdomen Easy bruising or bleeding Persistent vomiting or inability to keep fluids down Regarding bowel symptoms, seek medical advice if constipation: Persists despite lifestyle modifications for more than three weeks Is accompanied by rectal bleeding, blood in stools , or black, tarry stools (melaena) Causes severe abdominal pain or bloating Alternates with diarrhoea (which may suggest irritable bowel syndrome or other conditions) Is associated with unexplained weight loss Occurs with severe continuous abdominal pain, vomiting, and inability to pass wind or stool (which may indicate bowel obstruction—seek urgent medical attention) Be aware of NICE guidance (NG12) on suspected colorectal cancer , which recommends urgent referral (within two weeks) for: Adults aged 40 and over with unexplained weight loss and abdominal pain Adults aged 50 and over with unexplained rectal bleeding Adults aged 60 and over with change to looser and/or more frequent stools persisting for six weeks or more , or with iron-deficiency anaemia Your GP may arrange a faecal immunochemical test (FIT) to help assess the need for urgent investigation if you have lower-risk symptoms

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