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3.2 Core antioxidant enzymes were reprogrammed in a stage- and cultivar-dependent manner We first profiled genes encoding the core antioxidant enzymes that constitute the primary defense against ROS — SOD s, CAT s and GPX s ( Figure 2 , Supplementary Figure S2 )

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Our results show that Irisin significantly improves mitochondrial function and modulates metabolic reprogramming under pathological conditions (Fig