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Most patients report feeling an energy boost—and a reduction in fatigue—within 24–48 hours after their B12 injection, with many noticing improvements as soon as a few hours post-treatment
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The most frequently reported side effects include gastrointestinal symptoms such as nausea, diarrhoea, vomiting, constipation, and abdominal pain , which affect a significant proportion of patients, particularly during dose escalation
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