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Besides its potential in inflicting macromolecular damage, ROS and RNS also cause indirect damage in other cellular tissues by activating several cellular stress-sensitive pathways, including (i) activation of the polyol pathway, (ii) formation of advanced AGE and its receptors (RAGE), (iii) activation of the PKC pathway, and (iv) increased glucose influx through the hexosamine pathway [19,20,21]
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