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The decline of endogenous GHK-Cu with age raises the most fundamental question: is restoring youthful GHK-Cu levels sufficient to meaningfully slow or reverse the tissue aging process in those systems where GHK-Cu is a limiting factor
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Similarly, the higher methylation level at the natural cytotoxicity receptor (NCR) member Nkp46 locus was observed in NK cells from patients with head and neck squamous cell carcinoma (HNSCC), reflecting the extensive dysregulation of DNA methylation in NK cells under cancer contexts [166]
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