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After accounting for $3.1 billion in net shared savings to ACOs, the remaining difference of $2.1 billion would represent federal savings from the program if benchmarks proved to be a perfect counterfactual in aggregate

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Microbial-Host Interaction Optimisation: Bonza Belly influences how the microbiome communicates with the canine immune system: Modulation of pattern recognition receptor signaling (like TLR4) that can drive inappropriate inflammation in IBD Enhanced intestinal regulatory T-cell function promoting immune tolerance Improved intestinal dendritic cell function, balancing immune responses to microbial antigens Reduced bacterial translocation through enhanced barrier function, preventing inappropriate immune activation This improved host-microbe dialogue lies at the heart of sustainable IBD management, addressing root causes rather than merely suppressing symptoms