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Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end | Communications Biology

Although the original TALED has significant RNA targeting effect and cytotoxicity, the substrate binding site of its deaminase TadA8e has been modified through protein engineering, and a high fidelity variant has been successfully developed, which can reduce RNA targeting editing by more than 99%, and eliminate the toxicity to mouse embryo development, laying the foundation for the generation of disease models and safe treatment of Leigh syndrome [415]

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Discussing Weight and Energy Concerns Bring your medical history, medications, supplements, and previous weight-management efforts